At least 33 countries with tropical, subtropical and temperate climates have reported buruli ulcer in africa, south america and western pacific regions. Buruli ulcer, an infectious disease caused by mycobacterium ulcerans, is the third most preva lent mycobacteriosis, after tuberculosis and leprosy. Estimating buruli ulcer prevalence in southwestern ghana. Distribution of mycobacterium ulcerans in buruli ulcer endemic and nonendemic aquatic sites in ghana. Burden and historical trend of buruli ulcer prevalence in selected. Dr george amofah, public health division, ministry of health, accra, ghana. The overall crude national prevalence rate of active lesions was 20. This study aimed to assess the magnitude and epidemiology of bu in the south south region of nigeria. This retrospective study was to identify some challenges in the treatment of buruli ulcer bu and present a proposed treatment. Results of a national case search george amofah, frank bonsu, christopher tetteh, jane okrah, kwame asamoa, kingsley asiedu, and jonathan addy a national search for cases of buruli ulcer in ghana identified 5,619 patients, with 6,332 clinical lesions at various stages. Buruli ulcer disease is a health problem in tropical areas of many emerging countries. The ulcer may be larger inside than at the surface of the skin, and can be surrounded by swelling.
It mainly affects the skin but can also affect the bone. Challenges associated with management of buruli ulcerhuman. Laboratory diagnosis of buruli ulcer a manual for health care providers this manual provides expert guidance on the laboratory techniques and procedures used in the diagnosis of buruli ulcer, a disease caused by mycobacterium ulcerans. Buruli ulcer bu was identified about a century ago, and it is generally referred to as a reemerging disease particularly in west africa, including ghana where the prevalence in some villages is higher than tuberculosis. The case search demonstrated widespread disease and gross underreporting compared with the routine reporting system. Buruli ulcer commonly affects poor people who live near rivers or wetlands. Staffs working for who and ghana health service are tackling to buruli ulcer problems. Briefly, buruli ul cer is a skin disease caused by infection with mycobacterium ulcerans. The early stage of the infection is characterised by a painless nodule or area of swelling. Epidemiology of buruli ulcer in amansie west district, ghana.
A retrospective study was conducted in six different buruli ulcer bu treatment centers in benin and ghana. Buruli ulcer is a necrotizing skin disease that can leave patients with prominent scars and lifelong disability. Manual of basic techniques for a health laboratory. Buruli ulcer, caused by infection with mycobacterium ulcerans, is unfamiliar because it is common only among children in rural tropical areas, mainly in west africa. The method of transmission is uncertain but the bacteria can enter the skin if it is broken e. There was a significant difference in the age and sex composition, with more males among the younger. Challenges associated with management of buruli ulcerhuman immunodeficiency virus coinfection in a treatment center in ghana. Diagnosis of mycobacterium ulcerans infection buruli ulcer at a treatment centre in ghana. In the mouse footpad model for buruli ulcer, combination. The infection occurs in well defined areas throughout the world, mostly tropical areas in several areas in australia, in uganda, in several countries in west africa, in central and south america, in southeast asia and new guinea. Laboratory confirmation of buruli ulcer cases in ghana, 20082016.
Buruli ulcer is a disease caused by skin infection with mycobacterium ulcerans, an unusual mycobacterium that secretes a lipid toxin, mycolactone, which is responsible for the subcutaneous necrosis associated with ulcers. Treatment and prevention of mycobacterium ulcerans. This retrospective study was to identify some challenges in the treatment of buruli ulcer bu and present a proposed treatment regime. Buruli ulcer is a disease caused by the bacterium mycobacterium ulcerans.
Buruli ulcer, also known as bairnsdale ulcer, daintree ulcer, mossman ulcer, and searl ulcer, is a chronic, indolent, necrotizing disease of the skin and soft tissue. Buruli ulcer diagnostic ghana research note buruli ulcer bu was first described in 1897 in the present territory of uganda and mycobacterium ulcerans was first reported to be the etiologic agent by mac callum in 1948, in australia p mac callum et al. Diagnosis of mycobacterium ulcerans infection buruli. Although bu disease has been diagnosed among nigerians in neighbouring west african countries, data on the burden of the disease in nigeria itself are scanty. Buruli ulcer symptoms, diagnosis, treatments and causes. Reduction in rural ghana, 2003 mumma ga, whitney eas, dadzie f, etuaful s, ampadu e, dykewicz c, klutse e, ashford d, asiedu k. Buruli ulcer is an emerging infectious disease and is the third most common mycobacterial disease of the immunocompetent host, after tuberculosis and leprosy. Cases are generally seen in the tropics, primarily in west africa and australia. A total of 189 buruli ulcer patients from the bomfa. Buruli ulcer has been seen among people living in more than 30 countries around the world fig. Buruli ulcer, poverty, and poverty reduction in rural. Clinical and laboratory diagnosis of buruli ulcer disease. Buruli ulcer is a disease of high focal prevalence mainly within countries in west africa fig. A neglected but treatable disease that unnecessarily scars african children for life.
Buruli ulcer is the third most common mycobacterial disease of the immunocompetent host, after tuberculosis and leprosy it is caused by a toxinproducing mycobacteria, mycobacte. It is named after a region called buruli, near the nile river in uganda, where in 1961 the first large number of cases were reported. Edwin ampadu, the national focal person for bu at the disease control and prevention department of the ghana health service ghs, it is one of the most neglected but treatable tropical diseases. National buruli ulcer control programme ghana home. This paper describes 90 cases of buruli ulcer in amansie west district, ghana. Buruli ulcer, buruli ulcer signs and symptoms, buruli ulcer treatment, buruli ulcer risks, buruli ulcer disease, health care workers and buruli ulcer. In the paediatric surgical practice at the korlebu teaching hospital, 15 patients with confirmed buruli ulcers aged from. Buruli ulcer bu, the mycobacterium ulcerans skin ulcer, also known as bairnsdale ulcer, daintree ulcer, mossman ulcer, kumusi ulcer, tontokrom ulcer, and searles ulcer, is a chronic, indolent, and necrotizing disease of the skin and soft tissue caused by mycobacterium ulcerans mu, which usually begins as a painless nodule or papule and may progress to massive skin. Although cases have been reported from over 30 tropical and subtropical countries, it is currently most prevalent inwestafrica. Skip directly to site content skip directly to page options skip directly to az link skip directly to az link skip directly to az link. Information from patients medical records, hospital database, and followup findings on bu treatment procedures from 1994 to 1998 and from 2004 to 2007 at three research sites in ghana. Present status of buruli ulcer in ghana, west africa. Buruli ulcers scar, maim and bring misery to thousands of victims each year, but the culprit mycobacterium remains frustratingly difficult to understand.
The increase in incidence of buruli ulcer in ghana has also been complicated by problems in the care of the patients including lack of knowledge and training by staff, unwillingness of the staff to handle the. Although it has been reported in over 33 countries around the world, the greatest burden of disease is. With fogarty support, scientists have made inroads into understanding this clandestine disease, which crops up near swamps, wetlands, rivers and lakes, and seems tied to humanproduced changes. Hesse paediatric surgical unit, university of ghana medical school, p. The worst affected age group in this endemic region is mainly children aged 15 years and below.
Infection by a bacterium called mycobacterium ulcerans. Buruli ulcer is an infectious disease caused by mycobacterium ulcerans. Buruli ulcer is a skin disease caused by infection with mycobacterium ulcerans, which produces a potent toxin known as mycolactone, thus distinguishing itself from all other mycobacterial diseases. Pdf buruli ulcer bu is a disease affecting the skin, subcutaneous fat, and bone tissues. Buruli ulcer bu is a necrotizing cutaneous infection caused by.
Wound care is important in the prevention of disabilities. Buruli ulcer, is a devastating skin disease caused by mycobacterium ulcerans. Guidelines reflecting contemporary clinical practice in the management of buruli ulcer mycobacterium ulcerans infection in australia were published in 2007. University of groningen buruli ulcer in west africa klis. Pdf buruli ulcer bu, caused by mycobacterium ulcerans infection, is a debilitating disease of. This page is setup to help create awareness and advocacy on buruli ulcer in ghana. The disease occurs in tropical wetlands mainly in west africa, but there are significant foci elsewhere, particularly in temperate australia. Management has continued to evolve, as new evidence has become available from randomised trials, case series and increasing clinical experience with oral antibiotic therapy. The infection is most common in tropical and subtropical climates. Introduction buruli ulcer bu may be making patients and households who are not poor to drift into poverty, and those who are. Mycolactone destroys cells in the subcutis, leading to the development of large ulcers with undermined edges. Whether drug therapy can be shortened or not, an oral regimen for buruli ulcer treatment is urgently needed. Amofah regional health administration, ministry of health, p.
Buruli ulcer, caused by mycobacterium ulcerans, is a chronic, debilitating, necrotizing disease of the skin and soft tissue. Following a peak of 5954 reported bu cases globally in 2004 the number of new recorded cases has been decreasing over the. Wound care in buruli ulcer disease in ghana and benin article pdf available in the american journal of tropical medicine and hygiene 912 june 2014 with 563 reads doi. First, it will examine the geography of buruli ulcer bu in southwestern ghana and the variables that. Pdf wound care in buruli ulcer disease in ghana and benin. The result will be a model for estimating prevalence of buruli ulcer in selected places and regions. Buruli ulcer bu is a neglected, debilitating skin disease caused by infection with mycobacterium ulcerans. Buruli ulcer is a chronic debilitating disease caused by mycobacterium ulcerans. Box 1908, kumasi summary a total of 460 cases of buruli ulcer disease in va rious stages of development have so far been identi fied from il of the 18 disu. A national search for cases of buruli ulcer in ghana identified 5,619 patients, with 6,332 clinical lesions at various stages. Buruli ulcer is a disease caused by infection with mycobacterium ulcerans.
Bu patients clinically diagnosed between january 2012 and december 2016 were included and surgical interventions during the followup period, at. Author summary buruli ulcer bu is a tropical skin disease caused by. Significance of the thesis this thesis has two main goals. In ghana, nearly 1,200 bu cases were reported between 1993 and 1998 by. Buruli ulcer bu cases in seventyfive health facilities in ghana. Summary buruli ulcer is a chronic skin ulcer caused by the organism mycobacterium ulcerans. Buruli ulcer bu, also known as mycobacterium ulcerans disease, is the third most common mycobacterial disease worldwide. Augustin guedenon this document was published with contributions from the association francaise raoul follereau, paris, france and the nippon foundation, tokyo, japan. It often affects the skin and sometimes bone, and can lead to permanent disfigurement and longterm disability. Author summary buruli ulcer bu, a necrotizing skin disease caused by. Searching for causes of buruli ulcers in ghana fogarty. Enhancing buruli ulcer control in ghana through social.134 1550 278 1137 1100 261 732 1025 400 428 1077 1226 381 190 430 1058 1575 1404 275 56 1223 31 1105 579 1305 1091 913 934 956 1230 632 289 1125 601 593